Apple released i-Tunes 6.0.1 today. You need to run the Multi-Plugin 2.2 setup again to uninstall it, then run it again to re-install. All your skins will still be there. I just noticed today that i-Tunes 6.0 broke my i-pod. The i-pod wouldn't play a lot of my music- the player would just skip the songs by itself, sometimes several at a time until it found a track it was able to play. I installed 6.0.1 and re-synced, now everything is well again.
MP 2.2 (once you re-install it) seems to be working fine, as well as the new Milk skin.
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