Font Smoothing
from the two built in ones, Cleartype DEFINITELY..
cleartype is the best way or there is an app called clearertype as well that takes it a little further http://www.545studios.com
Thanks peteross for the link to that and many other great apps. I thought the only way to tweak cleartype was through that website but I guess I was wrong. Oh yeah, and bhound89, I LOVE your sig man. What it says is SOOO Freaking true! Peace, Love, and Sushi all the way baby, YEA!
it's weird, I don't see any difference though using clearertype tool. 
I too dont see any difference.. I played around with it quite a bit. 
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